L-glutamic acid, a modulator of the physiological state of myeloid blood cells

Authors
Astapova, MV Lipkin, VM Arkhipova, MV Andreeva, SG Dranitsyna, SM Merkulova, MI Nurieva, RI Navolotskaya, EV Kostanyan, IA
Citation
Mv. Astapova et al., L-glutamic acid, a modulator of the physiological state of myeloid blood cells, BIOORG KHIM, 25(11), 1999, pp. 816-820
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANICHESKAYA KHIMIYA
ISSN journal
01323423 → ACNP
Volume
25
Issue
11
Year of publication
1999
Pages
816 - 820
Database
ISI
SICI code
0132-3423(199911)25:11<816:LAAMOT>2.0.ZU;2-W
Abstract
The effects of L-glutamic acid on the differentiation of HL-60 and K-562 ce ll lines and on the expression level of mRNAs encoding IL-1 beta, IL-6, and TNF alpha were studied. It was shown that TNF alpha actively induces the d ifferentiation of these cell lines, whereas L-glutamic acid enhances its ef fect. Our results indicated that L-glutamic acid modulates the physiologica l state of the myeloid cell line in blood, in particular, by affecting both the reception and expression of cytokines functionally important for these cells.