The preparation and some properties of a liposome formulation of 2,4-Di(1-methyl-3-hydroxybutyl)deuteroporphyrin IX

A liposome preparation of a porphyrin photosensitizer for photodynamic ther apy of tumors (PDT) was obtained. The in vitro efficiency of the photosensi tizer was enhanced 2.5-fold through the liposome formulation. The compositi on and some properties of the new preparation were studied. An algorithm fo r a complex approach to the prediction of photosensitizer efficiencies by m odel experiments in vitro was developed. This approach is based on the use of two models: the determination of coefficient of distribution between n-o ctanol and a phosphate buffer, pH 7.4, and the determination of the cytotox ic effect on the culture of CaOv ovarian adenocarcinoma cells.