In an effort to characterize thyroid, gonadal and adrenal function followin
g neurotrauma, the present study determined serum concentrations of thyroid
-stimulating hormone (TSH), total triiodothyronine (T-3), thyroxine (T-4),
testosterone and cortisol over a 7 day period in 31 patients with traumatic
brain injury. The study group consisted of eight patients with mild closed
head injury (Glasgow Coma Scale-GCS 13-15), 10 patients with extensive pen
etrating head injury (GCS 4-6) and 13 patients with blast injuries but with
out direct head trauma. The latter group was included in the study because
the development of indirect brain trauma has previously been implicated in
blast injuries. Patients with multiple injuries were not included. Followin
g mild injury (GCS 13-15), TSH was increased up until day 3 after injury. T
-3 levels were elevated on days 1, 5 and 7 after injury while T-4 remained
unchanged throughout. While testosterone was decreased over only the first
2 days post-trauma, cortisol was increased over these first 2 days after in
jury. In contrast, following severe penetrating injury (GCS 4-6), there wer
e significant declines in TSH, T-3 and testosterone over the 7 day observat
ion period post trauma. Serum cortisol also declined in these patients betw
een 1-3 days after injury, before increasing again on days 5 and 7 after in
jury. Following indirect neurotrauma, TSH was slightly decreased immediatel
y after trauma but increased to above normal levels on days 5 and 7 post-tr
auma. Similarly, T-3 initially declined after injury, but then increased to
above normal levels between 5 and 7 days after injury. T-4 and testosteron
e remained unchanged over the entire post-traumatic period. Serum cortisol
was significantly increased after indirect neurotrauma but only up to day 2
post-trauma. In summary, patients with both direct and indirect traumatic
brain injury demonstrated endocrine alterations after trauma, the dynamics
of which may be a reflection of the severity of brain damage.