We report a case of patchy full thickness skin necrosis following drug over
dose with amitriptyline, that required excision and split skin grafting. To
our knowledge this is the first report of amitriptyline induced skin necro
sis that can be definitively attributed to this drug. The implications of d
rug related skin necrosis for the surgeon are discussed. (C) 1999 Elsevier
Science Ltd and ISBI. All rights reserved.