A giant cell angiofibroma involving 6q

Giant cell angiofibroma, a recently proposed new clinicopathological entity , arises exclusively in the orbit in adults and histologically exhibits fea tures intermediate between those of giant cell fibroblastoma and solitary f ibrous tumor. In a typical case of giant cell angiofibroma, abnormalities o f chromosome 6 with a common pattern involving 6q13 were detected together with various other chromosomal aberrations. To our knowledge, this is the f irst reported case of giant cell angiofibroma demonstrating chromosomal abn ormalities. (C) 1999 Elsevier Science Inc., 1999. All rights reserved.