Involvement of chromosomes 1 and 18 in renal cell tumors

Citation
P. Dal Cin et al., Involvement of chromosomes 1 and 18 in renal cell tumors, CANC GENET, 116(1), 2000, pp. 54-58
Citations number
12
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
01654608 → ACNP
Volume
116
Issue
1
Year of publication
2000
Pages
54 - 58
Database
ISI
SICI code
0165-4608(20000101)116:1<54:IOC1A1>2.0.ZU;2-Q
Abstract
A previously undescribed combination of cytogenetic abnormalities was detec ted in two renal cell tumors, one eosinophilic variant of the chromophilic type of renal cell carcinoma, and one oncocytoma. Both tumors shared loss o f Ip material and monosomy 18. These complex changes, while being unusual, indicate that chromosome Ip rearrangements, rather than associated numerica l changes, seem to play a crucial role in the development of renal tumors. (C) Elsevier Science Inc., 1999. All rights reserved.