A previously undescribed combination of cytogenetic abnormalities was detec
ted in two renal cell tumors, one eosinophilic variant of the chromophilic
type of renal cell carcinoma, and one oncocytoma. Both tumors shared loss o
f Ip material and monosomy 18. These complex changes, while being unusual,
indicate that chromosome Ip rearrangements, rather than associated numerica
l changes, seem to play a crucial role in the development of renal tumors.
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