Analysis of Li-Fraumeni syndrome and Li-Fraumeni-like families for germline mutations in Bcl10

The Li-Fraumeni syndrome (LFS) is a dominant disease whose hallmark is an i ncreased risk of breast cancers, brain tumours, sarcomas, leukaemia and adr enal carcinoma. Some, but not all LFS and Li-Fraumeni-like (LFL) families a re caused by TP53 mutations. Bcl10 is a recently identified tumour suppress or reported to be commonly mutated in a wide range of cancers, To investiga te the possibility that Bcl10 is a susceptibility gene for LFS and LFL we h ave analysed 27 LFS/LFL families. No mutations were observed. This indicate s that Bcl10 is unlikely to act as a susceptibility gene for LFS and LFL. ( C) 1999 Elsevier Science Ireland Ltd. All rights reserved.