Antithrombotic activity of the superoxide dismutase chondroitin sulfate complexes in a rat model of arterial injury

Authors
Maksimenko, AV Tischenko, EG Golubykh, VL
Citation
Av. Maksimenko et al., Antithrombotic activity of the superoxide dismutase chondroitin sulfate complexes in a rat model of arterial injury, CARDIO DRUG, 13(6), 1999, pp. 479-484
Citations number
48
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
CARDIOVASCULAR DRUGS AND THERAPY
ISSN journal
09203206 → ACNP
Volume
13
Issue
6
Year of publication
1999
Pages
479 - 484
Database
ISI
SICI code
0920-3206(199911)13:6<479:AAOTSD>2.0.ZU;2-K
Abstract
Individual antithrombotic activities of superoxide dismutase (SOD) and sodi um chondroitin sulfate (CHS) as well as the activities of covalent and nonc ovalent complexes of SOD with CHS were compared in a rat model of arterial thrombosis induced by ferrous chloride. Covalent conjugate of SOD with CHS exerted the most potent antithrombotic effect, which was associated with ad sorption of the conjugate on the glycocalyx of the vascular wall cells and stability of the covalent bond between CHS and SOD subunits. Theoretical an d practical directions in the investigation of SOD and CHS preparations are outlined.