The relationship between the levels of granulocyte colony-stimulating factor and leukocytosis induced by all-trans retinoic acid in acute promyelocytic leukemia
W. Wu et al., The relationship between the levels of granulocyte colony-stimulating factor and leukocytosis induced by all-trans retinoic acid in acute promyelocytic leukemia, CHIN MED J, 112(12), 1999, pp. 1085-1087
Objective To explore the mechanism of leukocytosis.
Methods Enzyme linked immunosorbent assay (ELISA) method was used for detec
ting levels of serum granulocyte colony-stimulating factor (G-CSF) in 47 ca
ses of acute promyelocytic leukemia (APL) during the treatment with all-tra
ns retinoic acid (ATRA).
Results The peak of increased serum G-CSF level occurred on the 9th day, an
d WBC number was the highest on the 11th day. After ATRA treatment, both se
rum G-CSF level and WBC number increased in 68.1% of the cases. In 19.2% of
the cases treated, serum G-CSF level was increased but without obvious cha
nge in WBC number, and the reverse was true in 12.7% of the cases.
Conclusion Serum G-CSF level was statistically correlated to the number of
WBC, promyelocytes and its late stage by Spearman's rank-order correlation
coefficient.