Gg. Miller et al., Longitudinal analysis of fibroblast growth factor expression after transplantation and association with severity of cardiac allograft vasculopathy, CIRCULATION, 100(24), 1999, pp. 2396-2399
Citations number
9
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Background-Vascular smooth muscle cell growth factors are postulated to con
tribute to cardiac allograft vasculopathy (CAV). Few data quantitatively ad
dress the timing, location, or stimuli for growth factor expression and rel
ationship to CAV.
Methods and Results-Acidic fibroblast growth factor (aFGF) mRNA expression
was determined in serial endomyocardial biopsies during the first year afte
r transplantation. Patients with high levels of aFGF mRNA and elevations af
ter the early posttransplant period had significantly more severe CAV than
patients with low aFGF and no late elevations.
Conclusions-Parenchymal aFGF expression varies between patients and in the
same patient over time and correlates with development of CAV.