The effect of G-CSF on the composition of human bone marrow

Authors
Tegg, EM Tuck, DM Lowenthal, RM Marsden, KA
Citation
Em. Tegg et al., The effect of G-CSF on the composition of human bone marrow, CLIN LAB H, 21(4), 1999, pp. 265-270
Citations number
23
Categorie Soggetti
Hematology
Journal title
CLINICAL AND LABORATORY HAEMATOLOGY
ISSN journal
01419854 → ACNP
Volume
21
Issue
4
Year of publication
1999
Pages
265 - 270
Database
ISI
SICI code
0141-9854(1999)21:4<265:TEOGOT>2.0.ZU;2-H
Abstract
The effects on bone marrow cellularity and morphology of 6 days' treatment with granulocyte colony-stimulating factor (G-CSF) in 35 patients were stud ied. Examination of trephine biopsies showed a highly significant increase in cellularity (P < 10(-13)). Assessment of aspirates revealed an increase in the myeloid to erythroid (M : E) ratio (P = 0.00006), the proportion of myeloid cells (P < 10(-8)), myelocytes (P = 0.00007), metamyelocytes (P = 0 .04), band forms (P = 0.0005) and neutrophils (P = 0.02). This study presen ts a comprehensive analysis of the effects of six days' administration of G -CSF on human bone marrow.