Azathioprine-associated acute myeloid leukaemia with trilineage dysplasia and complex karyotype: a case report and review of the literature

Authors
Arnold, JA Ranson, SA Abdalla, SH
Citation
Ja. Arnold et al., Azathioprine-associated acute myeloid leukaemia with trilineage dysplasia and complex karyotype: a case report and review of the literature, CLIN LAB H, 21(4), 1999, pp. 289-292
Citations number
21
Categorie Soggetti
Hematology
Journal title
CLINICAL AND LABORATORY HAEMATOLOGY
ISSN journal
01419854 → ACNP
Volume
21
Issue
4
Year of publication
1999
Pages
289 - 292
Database
ISI
SICI code
0141-9854(1999)21:4<289:AAMLWT>2.0.ZU;2-H
Abstract
A 66-year-old female with dermatomyositis (DM) who had received immunosuppr essive therapy with azathioprine developed acute myeloid leukaemia (AML). C ytogenetic analysis revealed a complex karyotype including monosomy 7, and trilineage dysplastic features strongly suggestive of a treatment-related a etiology. The literature on azathioprine-associated AML is reviewed.