Designed molecules that fold to mimic protein secondary structures

Citation
Kd. Stigers et al., Designed molecules that fold to mimic protein secondary structures, CURR OP C B, 3(6), 1999, pp. 714-723
Citations number
51
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CURRENT OPINION IN CHEMICAL BIOLOGY
ISSN journal
13675931 → ACNP
Volume
3
Issue
6
Year of publication
1999
Pages
714 - 723
Database
ISI
SICI code
1367-5931(199912)3:6<714:DMTFTM>2.0.ZU;2-7
Abstract
Molecules that fold to mimic protein secondary structures have emerged as i mportant targets of bioorganic chemistry. Recently, a variety of compounds that mimic helices, turns, and sheets have been developed, with notable advances in the design of beta-peptides that mimic each of these structures. These compounds hold promise as a step towa rd synthetic molecules with protein-like properties and as drugs that block protein-protein interactions.