Novel ways to prevent proteolysis - prophytepsin and proplasmepsin II

Authors
Bernstein, NK James, MNG
Citation
Nk. Bernstein et Mng. James, Novel ways to prevent proteolysis - prophytepsin and proplasmepsin II, CURR OP STR, 9(6), 1999, pp. 684-689
Citations number
36
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CURRENT OPINION IN STRUCTURAL BIOLOGY
ISSN journal
0959440X → ACNP
Volume
9
Issue
6
Year of publication
1999
Pages
684 - 689
Database
ISI
SICI code
0959-440X(199912)9:6<684:NWTPP->2.0.ZU;2-G
Abstract
The recently determined crystal structures of two aspartic proteinase zymog ens, prophytepsin from barley and proplasmepsin II from the malarial parasi te Plasmodium falciparum, have provided new insights into zymogen inactivat ion. Prophytepsin shows a variation of the mechanism of inhibition used by the well-known gastric aspartic proteinase zymogens, whereas proplasmepsin II uses a completely new mode of inactivation.