We use a national cross-sectional database, the 1880 Integrated Public Use
Microdata Sample, to examine aggregate patterns and individual-level estima
tes of chronic-disease morbidity and long-term disability in the United Sta
tes in the late nineteenth century. Despite higher levels of urban mortalit
y in 1880, morbidity prevalence pales were highest in the rural areas of th
e country, especially in the western and the southern regions. Equations us
ing microdata show that the estimated risk of chronic disease and impairmen
t was highest for males and females who were older, of lower socioeconomic
status, or from rural areas. This era was marked by geographically uneven b
ut significant levels of endemic chronic disease, likely the outcomes of pr
ior episodes of infectious disease and exposure to conditions generated by
human action, such as the Civil War and migration.