This paper explores the parenting of drug-dependent women and the contribut
ions of comorbid psychopathology to their parenting. A sample of 32 childre
n whose mothers were dependent on opioid drugs during pregnancy and 37 chil
dren whose mothers were not drug users were followed from birth to middle c
hildhood. Multivariate regression analyses were conducted contrasting wheth
er maternal substance abuse or psychopathology was more closely linked to p
arenting behaviors and continuity in parenting over time: Maternal drug dep
endence was related to whether mothers were able to remain primary caregive
rs for their children over time, even after controlling for psychopathology
. Maternal drug use was related to unresponsive and negative parenting beha
vior during mother-infant interaction, but this relation was largely accoun
ted for by the effects of comorbid maternal psychopathology on parenting, p
articularly symptoms of antisocial and related personality disorders. For t
hose children whose mothers continued to care for them into middle childhoo
d, perceptions of their mothers as rejecting were related to maternal antis
ocial personality and maternal depression. Substance-abuse treatment for wo
men should be integrated with interventions addressing their mental health
and parenting needs.