A. Cihan et al., Fournier's gangrene after hemorrhoidectomy: Association with drug-induced agranulocytosis - Report of a case, DIS COL REC, 42(12), 1999, pp. 1644-1648
An unusual case of Fournier's gangrene after hemorrhoidectomy and drug-indu
ced agranulocytosis, as the predisposing condition, is described. The patie
nt had severe granulocytopenia that was attributed to the recent use of dip
yrone. Together with hemodynamic resuscitation, broad-spectrum antibiotic a
nd recombinant human granulocyte colony-stimulating factor were started. Wi
de surgical excision of all the gangrenous tissues, in addition to laparosc
opic formation of a defunctioning sigmoid loop colostomy, was performed. Th
e white blood cell count rose steadily and the patient experienced a rapid
recovery. We emphasize that radical surgery must be accompanied by pharmaco
logic interventions for a successful outcome in such cases.