Fournier's gangrene after hemorrhoidectomy: Association with drug-induced agranulocytosis - Report of a case

Citation
A. Cihan et al., Fournier's gangrene after hemorrhoidectomy: Association with drug-induced agranulocytosis - Report of a case, DIS COL REC, 42(12), 1999, pp. 1644-1648
Citations number
35
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
DISEASES OF THE COLON & RECTUM
ISSN journal
00123706 → ACNP
Volume
42
Issue
12
Year of publication
1999
Pages
1644 - 1648
Database
ISI
SICI code
0012-3706(199912)42:12<1644:FGAHAW>2.0.ZU;2-K
Abstract
An unusual case of Fournier's gangrene after hemorrhoidectomy and drug-indu ced agranulocytosis, as the predisposing condition, is described. The patie nt had severe granulocytopenia that was attributed to the recent use of dip yrone. Together with hemodynamic resuscitation, broad-spectrum antibiotic a nd recombinant human granulocyte colony-stimulating factor were started. Wi de surgical excision of all the gangrenous tissues, in addition to laparosc opic formation of a defunctioning sigmoid loop colostomy, was performed. Th e white blood cell count rose steadily and the patient experienced a rapid recovery. We emphasize that radical surgery must be accompanied by pharmaco logic interventions for a successful outcome in such cases.