The reduction in propofol-induced pain on injection caused by the addition
of lignocaine results mainly from a drop in pH, which reduces the concentra
tion of propofol in the aqueous phase of the emulsion. It is not an effect
of the local anaesthetic per se. Propofol emulsion mixed with lignocaine de
stabilizes within hours. We mixed 10 parts of propofol 1% emulsion with one
part of 0.0064 m HCl or 0.013 m HCl, respectively. These mixtures were sto
red for 3 months and compared with a freshly prepared solution of propofol
1% emulsion and saline, in the same proportion, regarding their ability to
induce anaesthesia in the rat. There was no significant difference in the a
mount of propofol required to induce anaesthesia, nor was there any differe
nce in recovery time between the three groups.