Effects of controlled hypotension with sevoflurane anaesthesia on hepatic function of surgical patients

The effects of controlled hypotension induced with trimethaphan (TMP), nitr oglycerin (TNG) or prostaglandin E-1 (PGE(1)) during sevoflurane anaesthesi a on hepatic function were studied in 28 patients undergoing spinal fusion surgery. Patients were randomly divided into three groups to receive TMP (g roup A, n=10), TNG (group B, n=10) or PGE(1) (group C, n=8). Anaesthesia wa s maintained with N2O and sevoflurane. The mean arterial blood pressure was maintained at 60 mmHg for 90 min. Measurements included arterial ketone bo dy ratio (AKBR-acetoacetate/3-hydroxybutyrate), SGOT, SGPT, LDH, blood gluc ose and blood gases were made. Measurements were taken before hypotension, 60 min and 90 min after starting hypotension, 60 min after recovery from hy potension and on the post-operative day. AKBR showed no significant change. SGOT, SGPT and LDH were within normal limits. Controlled hypotension induc ed with TMP, TNG or PGE(1) under sevoflurane anaesthesia in surgical patien ts did not cause hepatocellular damage.