Synthesis and antispasmodic activity of analogues of natural pterosins

Authors
Sheridan, H Frankish, N Farrell, R
Citation
H. Sheridan et al., Synthesis and antispasmodic activity of analogues of natural pterosins, EUR J MED C, 34(11), 1999, pp. 953-966
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN journal
02235234 → ACNP
Volume
34
Issue
11
Year of publication
1999
Pages
953 - 966
Database
ISI
SICI code
0223-5234(199911)34:11<953:SAAAOA>2.0.ZU;2-0
Abstract
The synthesis of an extensive range of analogues of natural pterosins using modified Heck coupling is reported. The smooth muscle relaxant activity of these compounds has been examimed. Several compounds with significant smoo th muscle relaxant activity have been identified. (C) 1999 Editions scienti fiques et medicales Elsevier SAS.