Ie. Bylov et al., Synthesis and anti-inflammatory activity of N-substituted 2-oxo-2H-1-benzopyran-3-carboxamides and their 2-iminoanalogues, EUR J MED C, 34(11), 1999, pp. 997-1001
A series of N-arylsubstituted 2-imino-2H-1-benzopyran-3-carboxamides 3a and
b and 2-oxo-2H-1-benzopyran-3-carboxamides 4a-h were synthesized and evalu
ated for their anti-inflammatory activity in carrageenan-induced rat paw oe
dema assays and in acetic acid-induced peritonitis tests in albino rats. Th
e resulting products were found to be active anti-inflammatory agents and t
heir effects were comparable to that of piroxicam as the reference compound
. In the consideration of the efficacy of the compounds in these assays, 2-
imino/oxo-2H-1-benzopyran-3-carboxamides 3a and b and 4a-h were further stu
died at graded doses for their acute toxicity (ALD(50)) in albino mice and
were essentially non-toxic at the highest dose tested. (C) 1999 Editions sc
ientifiques et medicales Elsevier SAS.