Expression analysis of 21 transcripts physically anchored within the chromosomal region 10q24

Chromosome band 10q24 harbors the critical regions for inherited neurologic al disorders such as partial epilepsy (EPT), urofacial syndrome, and a dist inct form of spastic paraparesis. To facilitate the selection of candidate genes for these diseases, we determined the mRNA sizes and analyzed the exp ression patterns of 21 brain transcripts defined by expressed sequence tags previously localized along a 7.4-Mb interval of 10q24. In addition to a nu mber of widely expressed transcribed sequences, we identified several trans cripts exclusively or predominantly expressed in the brain, which represent potential candidates for the neurological diseases associated with this ge nomic region. (C) 1999 Academic Press.