Uterine pleomorphic rhabdomyosarcoma in a patient receiving tamoxifen therapy

Introduction. Tamoxifen has been used as adjuvant therapy for the treatment of breast cancer. Its use has been associated with the development of prol iferative endometrial lesions such as polyps, hyperplasia, and carcinoma. M esenchymal tumors including malignant mixed mullerian tumors, endometrial s tromal sarcomas, adenosarcomas, and leiomyosarcomas have been more recently described with tamoxifen use. Case report. This report describes the first case of a pure uterine rhabdom yosarcoma in a patient receiving tamoxifen therapy. Discussion. Although uterine rhabdomyosarcomas are rare tumors and may aris e de novo, we discuss the possible role of tamoxifen in the development of these mesenchymal tumors. (C) 1999 Academic Press.