Several systemic bacterial diseases have significant orofacial manifestatio
ns. Such manifestations include the streptococcal and staphylococcal exanth
ematous conditions, sexually transmitted diseases, actinomycosis, tuberculo
sis, and other less common conditions. Generally, the orofacial manifestati
ons are similar to lesions at other sites and may occur alone or concurrent
ly with lesions at other locations.