One million individuals in the United States alone are estimated to be curr
ent: or past users of anabolic-androgenic steroids. In the United States fi
fty-percent of anabolic-androgenic steroid users administer their compounds
intramuscularly, and twenty-five percent of adolescent anabolic-androgenic
steroid users share needles, placing these young adults at risk for infect
ions related to injection. To examine the medical literature for reports of
infections attributable to anabolic-androgenic steroids, we conducted a ME
DLINE (1966-1998) and AIDSLINE (1980-1998) world literature review to exami
ne all references that attributed infections to anabolic-androgenic steroid
injection. Infections associated with anabolic-androgenic steroid injectio
n include three cases of HIV, one case of hepatitis B, one case of hepatiti
s C, eight abscesses, and a case of fungal endophthalmitis. No cross-sectio
nal or prospective studies exist that document the risk of infections relat
ed to anabolic-androgenic steroid injection. These serious infectious compl
ications of anabolic-androgenic steroid injection may be avoided with educa
tion and prevention techniques. Infections occurring in anabolic-androgenic
steroid users are not as common as in intravenous drug users.