HEMORRHAGIC GASTROESOPHAGEAL ULCERATION BY PULMONARY INFECTION IN EXTRAHEPATIC CHOLESTATIC PIGS

We developed a biliary and pulmonary microbiologic study in 22 Large-W hite pigs that underwent bile-duct ligation in order to demonstrate th at sepsis has a biliary and pulmonary origin which may be involved in the gastroesophageal pathology. All the pigs died at 18.2 +/- 8.9 days of the post-operative period. The cause of death was hemorrhagic ulce ration of the gastroesophageal region in 36.3% (n=8) of the animals th at also presented multiple bilateral military lung abscesses. High inf estation rates with intestinal germs were found in the bile and lung. In conclusion, the experimental model of extrahepatic cholestasis in t he Large-White pig could be useful for the study of etiopathogenic mec hanisms by which the pulmonary infection produces a hemorrhagic gastro esophageal ulceration considered as stress ulcer.