Osteoporosis associated with non-familial acro-osteolysis - Successful treatment with an anti-resorptive agent

The syndrome non-familial acro-osteolysis features bone reabsorption of the digits in association with short stature. Osteoporosis is common in this d isorder, but no successful treatment has been previously reported. We repor t a case of non-familial acro-osteolysis complicated by multiple fractures in which treatment with antiresorptive therapy improved both biochemical ma rkers of bone turnover and bone mineral density but had no effect on the ac ro-osteolysis.