Mutations in catabolite control protein CcpA showing glucose-independent regulation in Bacillus megaterium

Authors
Kuster-Schock, E Wagner, A Volker, U Hillen, W
Citation
E. Kuster-schock et al., Mutations in catabolite control protein CcpA showing glucose-independent regulation in Bacillus megaterium, J BACT, 181(24), 1999, pp. 7634-7638
Citations number
35
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF BACTERIOLOGY
ISSN journal
00219193 → ACNP
Volume
181
Issue
24
Year of publication
1999
Pages
7634 - 7638
Database
ISI
SICI code
0021-9193(199912)181:24<7634:MICCPC>2.0.ZU;2-6
Abstract
We identified five single amino acid exchanges in CcpA that lead to permane nt repression of the xylose utilization genes in the absence of glucose, Ot her proteins from the CcpA regulon also show glucose-independent regulation in the mutants, The mutant CcpA proteins bind to the DNA target catabolite responsive elements without the corepressor HPr-Ser-P.