New fasciculol-type triterpene compounds from Hypholoma fasciculare

Authors
Kleinwachter, P Luhmann, U Schlegel, B Heinze, S Hartl, A Kiet, TT Grafe, U
Citation
P. Kleinwachter et al., New fasciculol-type triterpene compounds from Hypholoma fasciculare, J BASIC MIC, 39(5-6), 1999, pp. 345-349
Citations number
11
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF BASIC MICROBIOLOGY
ISSN journal
0233111X → ACNP
Volume
39
Issue
5-6
Year of publication
1999
Pages
345 - 349
Database
ISI
SICI code
0233-111X(1999)39:5-6<345:NFTCFH>2.0.ZU;2-V
Abstract
New fasciculol-type triterpene compounds 1, 2 and 3 were discovered in extr acts of the mushroom Hypholoma fasciculare by LC-NMR and LC-MS methods. Iso lation and structure elucidation are reported. Fasciculol and fasciculic ac id production of H. fasciculare was compared with that of H. sublateritium and H. capnoides. 1 and 2 inhibited moderately 3 alpha-hydroxysteroid dehyd rogenase (IC50: 14.0 mu M).