Synthesis of 2(3H)-benzoxazolinone derivatives as potential beta-3-adrenergic receptor ligands

Authors
Delhomel, JF Yous, S Depreux, P Lesieur, D
Citation
Jf. Delhomel et al., Synthesis of 2(3H)-benzoxazolinone derivatives as potential beta-3-adrenergic receptor ligands, J HETERO CH, 36(5), 1999, pp. 1241-1245
Citations number
15
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022152X → ACNP
Volume
36
Issue
5
Year of publication
1999
Pages
1241 - 1245
Database
ISI
SICI code
0022-152X(199909/10)36:5<1241:SO2DAP>2.0.ZU;2-5
Abstract
Beta-3-subtype-adrenoceptors mediate lipolysis and in the search for potent ial beta-3-adrenergic receptor agonists for the treatment of obesity, we de signed new arylethanolamines, structures B-1 and B-2, derived from 2(3H)-be nzoxazolinone. To obtain these target compounds as starting materials, vari ous N-benzyl-[2(3H)-benzoxazolinon- 6-yl]ethylamines were used.