Zoster incidence in human immunodeficiency virus-infected hemophiliacs andhomosexual men, 1984-1997

Citation
Ea. Engels et al., Zoster incidence in human immunodeficiency virus-infected hemophiliacs andhomosexual men, 1984-1997, J INFEC DIS, 180(6), 1999, pp. 1784-1789
Citations number
29
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
JOURNAL OF INFECTIOUS DISEASES
ISSN journal
00221899 → ACNP
Volume
180
Issue
6
Year of publication
1999
Pages
1784 - 1789
Database
ISI
SICI code
0022-1899(199912)180:6<1784:ZIIHIV>2.0.ZU;2-6
Abstract
Zoster is an important clinical problem for human immunodeficiency virus ty pe 1 (HIV)-infected patients. Risk factors for tester and trends in inciden ce in HIV-infected hemophiliacs and homosexual men (n = 1218) were examined . From 1984 to 1997, 174 tester cases were identified (average yearly incid ence, 2.5%). Prior tester episodes were associated with increased risk for a subsequent episode (relative risk [RR], 4.30; 95% confidence interval [CI ], 3.11-5.95), Among hemophiliacs, children and adolescents had the highest tester risk, and tester risk declined with age (RR, 0.80 per decade; 95% C I, 0.68-0.93), These findings suggest that HIV-infected persons do not prod uce or maintain adequate booster responses after varicella tester virus exp osure. Zoster risk was relatively constant when CD4 cell counts >200 cells/ mm(3) but increased steeply below this level. During the 14 years of follow -up, tester incidence declined 9% per year. This trend occurred despite dec reasing CD4 cell counts and was unexplained by zidovudine or acyclovir use.