Age-related changes in the epiglottis causing failure of nasal continuous positive airway pressure therapy

At 65 years of age, a former coal miner, now 72-years-old, developed a prog ressive loss of concentration with daytime sleepiness and sleep disturbance s. Work-up in pneumological and medical sleep centres resulted in diagnosis of chronic obstructive pulmonary disease (COPD), borderline obstructive sl eep apnoea syndrome and, later, upper airway resistance syndrome. In additi on, there was evidence of reduced efficiency of sleep. Neither the initial administration of theophylline nor the later use at night of hyperbaric res piration led to improvement in the patient's symptoms. Instead, the patient developed loud snoring, as well as the inability to sleep while in a lying position. At age 71 years, otorhinolaryngological examination resulted in findings of age-related changes in the epiglottis, that completely blocked the hypopha rynx upon inspiration. Polysomnography, which was possible only in a half-s eated position, revealed reduction in deep sleep, with a maximum oxygen sat uration of 77 per cent at an apnoea-hypopnoea index (AHI) of 4.8. Partial resection of the epiglottis with laser surgery resulted in complete improvement of diurnal drowsiness and reduced stamina. Sleeping in a supin e position again became possible. Polysomnography revealed normalization of sleep architecture, but unchanged, low efficiency of sleep. This case underscores the importance of an interdisciplinary approach to th e treatment of sleep-related breathing disorders.