AGYRIA-PACHYGYRIA - CEREBRAL PERFUSION STUDIES BY TC-99M-HMPAO

Cerebral perfusion was investigated in three patients with agyria-pach ygyria by using Tc-99m-HMPAO SPECT in order to study the distribution of blood flow, Diffuse cortical hypoperfusion was found in all three i nfants. The visual cortex was not identifiable in two of the cases. Th e basal ganglia and cerebellum were prominent by their normal high act ivity, while tracer uptake was very low in the thalamus. The possible role of improper development of interneuronal connections and abnormal vascular pattern in background of the perfusion defect is discussed. (C) 1997 Elsevier Science B.V.