Stereochemical implications on diversity in beta-turn peptidomimetic libraries

Citation
Yb. Feng et al., Stereochemical implications on diversity in beta-turn peptidomimetic libraries, J ORG CHEM, 64(25), 1999, pp. 9175-9177
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
00223263 → ACNP
Volume
64
Issue
25
Year of publication
1999
Pages
9175 - 9177
Database
ISI
SICI code
0022-3263(199912)64:25<9175:SIODIB>2.0.ZU;2-X
Abstract
Stereoisomers of compound 1 were prepared, and their preferred solution-pha se conformations (in DMSO) were determined by a combination of NMR, CD, and molecular simulation approaches. It was shown that the stereochemistry of the pseudo i + 2 residue is the predominant consideration.