Determination of remifentanil in human heparinised whole blood by tandem mass spectrometry with short-column separation

Authors
Bender, J van den Elshout, J Selinger, K Broeders, G Dankers, J van der Heiden, C
Citation
J. Bender et al., Determination of remifentanil in human heparinised whole blood by tandem mass spectrometry with short-column separation, J PHARM B, 21(3), 1999, pp. 559-567
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN journal
07317085 → ACNP
Volume
21
Issue
3
Year of publication
1999
Pages
559 - 567
Database
ISI
SICI code
0731-7085(199911)21:3<559:DORIHH>2.0.ZU;2-H
Abstract
For the use in pharmacokinetic studies, a fast and sensitive assay method w as developed for the determination of remifentanil in human heparinised who le blood samples of 0.5 mi. The assay method is based on tandem mass spectr ometry detection (LC-MS/MS). The limit of quantification is 0.1 ng/ml and l inear up to 50 ng/ml. The precision, accuracy, recovery and applicability w ere found to be adequate for pharmacokinetic studies. (C) 1999 Elsevier Sci ence B.V. All rights reserved.