Stability of meperidine in an implantable infusion pump using capillary gas chromatography-mass spectrometry and a deuterated internal standard

Citation
Sc. Harvey et al., Stability of meperidine in an implantable infusion pump using capillary gas chromatography-mass spectrometry and a deuterated internal standard, J PHARM B, 21(3), 1999, pp. 577-583
Citations number
34
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN journal
07317085 → ACNP
Volume
21
Issue
3
Year of publication
1999
Pages
577 - 583
Database
ISI
SICI code
0731-7085(199911)21:3<577:SOMIAI>2.0.ZU;2-7
Abstract
A capillary gas chromatographic-mass spectrometric (GC-MS) method is descri bed for the analysis of meperidine using 3,3,5,5-[H-2(4)]-meperidine as an internal standard. Chromatography was performed on a (5% phenyl) methylpoly siloxane column (30 m x 0.32 mm I.D., 0.25 mu m film thickness) operated at 195 degrees C; helium carrier gas-50 cm s(-1), t(R) = 2.3 min. Ionization was by electron impact (EI) and detection by selected ion monitoring of the molecular ions. The method provided high response linearity (mean r = 0.99 82) and precision (<6.5% C.V.). Application of this method to a pilot study of aqueous meperdine . HCl (10 mg ml(-1)) stability in a surgically implan table infusion pump at 37 degrees C for 90 days revealed no demonstrable dr ug degradation. (C) 1999 Elsevier Science B.V. All rights reserved.