Vascular insufficiency of a peripheral limb is a well-recognized and s
erious complication occurring in newborn infants. A 15-year review of
a Level III neonatal intensive care unit at The Children's Hospital of
Eastern Ontario revealed 10 infants who had a vascular insult to a li
mb necessitating the amputation of a portion of the limb. Predisposing
factors to vascular occlusion were prematurity, polycythemia, umbilic
al artery catheterization, and intensive care treatment for other life
-threatening illnesses. The lower extremity was most commonly affected
, requiring below-knee amputations in two infants, knee disarticulatio
n in one, and toe amputations in five. The remaining infants required
an elbow disarticulation and amputation of the fingers, and one child
had a massive ischemic contracture of the lower limb. Care should be t
aken not to amputate prematurely and await definitive demarcation of t
he gangrenous portion. Amputation should be designed to preserve growt
h plates wherever possible to ensure an adequate stump for prosthetic
fitting in the older child.