Treatment of severe chronic digoxin toxicosis in a dog with cardiac disease, using ovine digoxin-specific immunoglobulin G Fab fragments

Citation
Dm. Ward et al., Treatment of severe chronic digoxin toxicosis in a dog with cardiac disease, using ovine digoxin-specific immunoglobulin G Fab fragments, J AM VET ME, 215(12), 1999, pp. 1808-1812
Citations number
19
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
ISSN journal
00031488 → ACNP
Volume
215
Issue
12
Year of publication
1999
Pages
1808 - 1812
Database
ISI
SICI code
0003-1488(199912)215:12<1808:TOSCDT>2.0.ZU;2-X
Abstract
Digoxin toxicosis, which results in clinical signs that include vomiting, d iarrhea, anorexia, and cardiac arrhythmias, may develop in dogs treated wit h digoxin. Ovine digoxin-specific IgG Fab fragments can be used to treat severe digoxi n toxicosis in dogs; however, management may be complicated because of prol onged loss of the positive inotropic effect of digoxin.