Treatment of severe chronic digoxin toxicosis in a dog with cardiac disease, using ovine digoxin-specific immunoglobulin G Fab fragments

Digoxin toxicosis, which results in clinical signs that include vomiting, d iarrhea, anorexia, and cardiac arrhythmias, may develop in dogs treated wit h digoxin. Ovine digoxin-specific IgG Fab fragments can be used to treat severe digoxi n toxicosis in dogs; however, management may be complicated because of prol onged loss of the positive inotropic effect of digoxin.