The influence of regional spinal cord hypothermia on transcranial myogenicmotor-evoked potential monitoring and the efficacy of spinal cord ischemiadetection
Sa. Meylaerts et al., The influence of regional spinal cord hypothermia on transcranial myogenicmotor-evoked potential monitoring and the efficacy of spinal cord ischemiadetection, J THOR SURG, 118(6), 1999, pp. 1038-1045
Citations number
28
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Objective: Myogenic motor-evoked responses to transcranial electrical stimu
lation (transcranial myogenic motor-evoked potentials) can rapidly detect s
pinal cord ischemia during thoracoabdominal aortic aneurysm repair. Recent
evidence suggests that regional spinal cord hypothermia increases spinal co
rd ischemia tolerance. We investigated the influence of subdural infusion c
ooling on transcranial myogenic motor-evoked potential characteristics and
the time to detect spinal cord ischemia in 6 pigs, Methods: Regional hypoth
ermia was produced by subdural perfusion cooling. A laminectomy and incisio
n of the dura were performed at L2 to advance 2 inflow catheters at L4 and
L6, to cool the lumbar subdural space with saline solution. Two temperature
probes were advanced at L3 and L5, and 1 cerebrospinal fluid pressure line
was advanced at L4. Spontaneous cerebrospinal fluid outflow was allowed. S
pinal cord ischemia was produced by clamping a set of critical lumbar arter
ies, previously identified by transcranial myogenic motor-evoked potentials
and lumbar artery clamping. The time between the onset of ischemia and det
ection with transcranial myogenic motor-evoked potentials (amplitude < 25%)
was determined at cerebrospinal fluid temperatures of 37 degrees C and 28
degrees C. Thereafter, the influence of progressive cerebrospinal fluid coo
ling on transcranial myogenic motor-evoked potential amplitude and latency
was determined. Results: The time necessary to produce ischemic transcrania
l myogenic motor-evoked potentials, after the clamping of critical lumbar a
rteries, was not affected at moderate subdural hypothermia (3.8 +/- 0.9 min
) compared with subdural normothermia (3.2 +/- 0.5 min; P =.6). Thereafter,
progressive cooling resulted in a transcranial myogenic motor-evoked poten
tial amplitude increase at 28 degrees C to 30 degrees C and was followed by
a progressive decrease. Response amplitudes decreased below 25 % at 14.0 d
egrees C +/- 1.1 degrees C. The influence of cerebrospinal fluid temperatur
e on transcranial myogenic motor-evoked potential amplitude was best repres
ented by a quadratic regression curve crith a maximum at 29.6 degrees C. In
contrast, transcranial myogenic motor-evoked potential latencies increased
linearly with decreasing subdural temperatures. Conclusions: Detection of
spinal cord ischemia with transcranial myogenic motor-evoked potentials is
not delayed at moderate subdural hypothermia in pigs, At a cerebrospinal fl
uid temperature of 28 degrees C, transcranial myogenic motor-evoked potenti
al amplitudes are increased. Further cerebrospinal fluid temperature decrea
ses result in progressive amplitude decreases and latency increases.