Leukemogenesis by CBF oncoproteins

The AML1 and CBF beta subunits of core binding factor (CBF) are involved in several chromosomal abnormalities frequently associated with acute leukemi as. As a result, the CBF beta-SMMHC, AML1-ETO and AML1-MDS1/EVI1 fusion pro teins are expressed in subsets of acute myeloid leukemia, and TEL-AML1 is e xpressed in B-lineage acute lymphocytic leukemia. These CBF oncoproteins li kely contribute to leukemogenesis in part by inhibiting endogenous CBF. As a result they are expected to inhibit differentiation and perhaps apoptosis . In addition, the domains unique to each fusion protein may also contribut e to leukemogenesis via unique mechanisms.