Peripheral progenitor cells (CFU-GM, BFU-E, CD34) are increased in untreated chronic lymphocyte leukemia patients: Stage B and C display a particularly high CD34(+) cell count

Authors
Berger, M Rapatel, C Boiret, N Halle, P Kanold, J Mareynat, G Tournilhac, O Albuisson, E Bonhomme, J Demeocq, F Travade, P
Citation
M. Berger et al., Peripheral progenitor cells (CFU-GM, BFU-E, CD34) are increased in untreated chronic lymphocyte leukemia patients: Stage B and C display a particularly high CD34(+) cell count, LEUK LYMPH, 35(5-6), 1999, pp. 587-591
Citations number
9
Categorie Soggetti
Hematology,"Onconogenesis & Cancer Research
Journal title
LEUKEMIA & LYMPHOMA
ISSN journal
10428194 → ACNP
Volume
35
Issue
5-6
Year of publication
1999
Pages
587 - 591
Database
ISI
SICI code
1042-8194(199911)35:5-6<587:PPC(BC>2.0.ZU;2-C
Abstract
No treatment has proved its efficiency in CLL. Autologous transplantation i s now under consideration for the youngest patients. We assayed progenitor cells (CFU-GM, BFU-E, CD34) in the peripheral blood of 28 untreated CLL pat ients and found an increase of all these progenitors in CLL compared to con trols. There was no statistical difference between stage A versus stages B and C for CFU-GM and BFU-E. In contrast, CD34 cells were higher in stages B and C as compared to stage A. This finding could be explained by a high nu mber of circulating clonal cells in advanced stages of the disease.