A 14-year-old girl developed maculopapular rash, myalgias, arthralgias and
myocarditis with elevated anti-nuclear and anti-double-stranded DNA antibod
ies. She was taking minocycline for acne and all symptoms resolved when thi
s treatment was stopped. The patient has no evidence of disease one year af
ter onset of symptoms. Clinicians should be aware of minocycline's responsi
bility in inducing lupus-like disease.