STUDIES ON ANTIANAPHYLACTIC ACTIVITY OF FRACTIONS OF ALBIZZIA LEBBECK

Two fractions (F079 and F080) of the hot aqueous extract of stem bark of Albizzia lebbeck have been evaluated for antianaphylactic/antialler gic activity in vitro and in vivo. Both fractions inhibited antigen-in duced contraction of the sensitized guinea pig ileum (Schultz-Dale phe nomenon). The bronchoconstriction induced by the antigen egg albumin i n presensitized guinea pig was also inhibited by these fractions in a dose-dependent manner. The fractions, however, did not possess any bro nchodilatory effect per se in nonsensitized animals.