Oxidative metabolic activity of polymorphonuclear neutrophils in HIV-infected patients

Citation
Pd. Dios et al., Oxidative metabolic activity of polymorphonuclear neutrophils in HIV-infected patients, MED CLIN, 113(17), 1999, pp. 652-654
Citations number
10
Categorie Soggetti
General & Internal Medicine
Journal title
MEDICINA CLINICA
ISSN journal
00257753 → ACNP
Volume
113
Issue
17
Year of publication
1999
Pages
652 - 654
Database
ISI
SICI code
0025-7753(19991120)113:17<652:OMAOPN>2.0.ZU;2-P
Abstract
BACKGROUND: Contradictory results on oxidative burst activity in HIV infect ion have been reported in the literature, PATIENTS AND METHODS: Neutrophil oxidative metabolism was evaluated in 160 HIV-infected patients, by measuring the intracellular production of rhodami ne. RESULTS: Neutrophil oxidative metabolism was decreased, This impairment was related to viral load, CD4(+) lymphocyte counts, neutrophil counts and the rapy. CONCLUSIONS: In HIV-infected patients, neutrophil oxidative metabolic activ ity decreases with disease progression. This may contribute to secondary op portunistic infections.