Synergistic effect of rapamycin and cyclosporine in prevention of acute kidney allograft rejection in the mouse

The effect of rapamycin (RAPA) and cyclosporine A (CsA) monotherapy and com bination therapy was examined in prevention of kidney allograft rejection i n the mouse. Both drugs were administered orally for up to 14 days in BALB/ c (H-2(d)) to C57BL/6 (H-2(b)) mice strong combination. Six groups were tre ated with RAPA and/or CsA. This study shows that concomitant therapy of RAP A and CsA produces strong synergistic interaction in prolonging renal allog raft survival in mice when compared with monotherapy of RAPA or CsA. (C) 19 99 Wiley-Liss, Inc.