Binding of HIV gp41 with its receptors immobilized at liquid/solid interface studied by surface plasmon resonance

Authors
Yang, J Sun, YT Wu, WC Chen, YH Sui, SF
Citation
J. Yang et al., Binding of HIV gp41 with its receptors immobilized at liquid/solid interface studied by surface plasmon resonance, MOL CRYST A, 337, 1999, pp. 465-468
Citations number
5
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS
ISSN journal
1058725X → ACNP
Volume
337
Year of publication
1999
Pages
465 - 468
Database
ISI
SICI code
1058-725X(1999)337:<465:BOHGWI>2.0.ZU;2-B
Abstract
A home-made SPR biosensor was used to monitor the interactions of gp41 with its binding proteins in real time. The result indicates that the polystyre ne biosensor film is useful for SPR detection. The binding constants indica te both P45 and P62 have a high affinity to the protein gp41, and suggest t hat P45 and P62 may be the cellular receptors on human T-, B-lymphocytes an d monocytes.