Intracerebral hemorrhage outcome: Apolipoprotein E genotype, hematoma and edema volumes

Authors
McCarron, MO Hoffmann, KL DeLong, DM Gray, L Saunders, AM Alberts, MJ
Citation
Mo. Mccarron et al., Intracerebral hemorrhage outcome: Apolipoprotein E genotype, hematoma and edema volumes, NEUROLOGY, 53(9), 1999, pp. 2176-2179
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
53
Issue
9
Year of publication
1999
Pages
2176 - 2179
Database
ISI
SICI code
0028-3878(199912)53:9<2176:IHOAEG>2.0.ZU;2-B
Abstract
We investigated whether early hematoma or edema volumes could explain the a dverse association between APOE epsilon 4 and survival in intracerebral hem orrhage. Among 102 patients, epsilon 4 carriers had a higher mortality rate than non-epsilon 4 carriers (38 versus 24%, p = 0.05). Nonsurvivors had la rger hematoma (75.5 cm(3) versus 27.1 cm(3), p < 0.001) and edema volumes ( 37.5 cm(3) versus 17.1 cm(3), p < 0.01), but these were not associated with epsilon 4 after adjusting for race, age, and type of hemorrhage.