Reduction of tyrosine kinase B and tyrosine kinase C inductions by treatment with neurotrophin-3 after transient middle cerebral artery occlusion in rat

Authors
Zhang, WR Hayashi, T Wang, JM Sasaki, C Sakai, K Warita, H Shiro, Y Suenaga, H Ohmae, H Tsuji, S Itoh, T Nishimura, O Nagasaki, H Abe, K
Citation
Wr. Zhang et al., Reduction of tyrosine kinase B and tyrosine kinase C inductions by treatment with neurotrophin-3 after transient middle cerebral artery occlusion in rat, NEUROSCI L, 276(3), 1999, pp. 161-164
Citations number
14
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
03043940 → ACNP
Volume
276
Issue
3
Year of publication
1999
Pages
161 - 164
Database
ISI
SICI code
0304-3940(199912)276:3<161:ROTKBA>2.0.ZU;2-P
Abstract
Infarct volume and immunoreactivities for trkB and trkC in rat brain were c ompared at 24 h after 90 min of transient middle cerebral artery occlusion (MCAO) between animal groups with or without neurotrophin-3 (NT-3, 10 mu g/ 250 g animal). Treatment of rat brain with topical application of NT-3 sign ificantly reduced infarct volume (P = 0.02) and trkB and trkC inductions. T hese data suggest that NT-3 reduced the ischemic injury along with the redu ction of trkB and trkC inductions. (C) 1999 Elsevier Science Ireland Ltd. A ll rights reserved.