Giant cell angiofibroma of the buccal mucosa

We report a case of a patient with a recently described entity (giant cell angiofibroma) occurring in the oral cavity. A submucosal solid tumor arisin g in the right buccal mucosa of a 46-year-old woman was histologically char acterized by a patternless spindle-cell proliferation within a generally my xoid stroma containing areas of perivascular sclerosis. Numerous multinucle ated giant cells of the floret type were present. Immunohistochemically, th e tumor cells and multinucleated giant cells exhibited positivity for CD34. To the best of our knowledge, this is the first report of a giant cell ang iofibroma arising in the oral cavity.