Development of irreversible lesions in the brain, heart and kidney following acute and chronic murine malaria infection

Citation
Pn. Vuong et al., Development of irreversible lesions in the brain, heart and kidney following acute and chronic murine malaria infection, PARASITOL, 119, 1999, pp. 543-553
Citations number
26
Categorie Soggetti
Microbiology
Journal title
PARASITOLOGY
ISSN journal
00311820 → ACNP
Volume
119
Year of publication
1999
Part
6
Pages
543 - 553
Database
ISI
SICI code
0031-1820(199912)119:<543:DOILIT>2.0.ZU;2-H
Abstract
Irreversible pathological lesions were noted in the organs of mice infected with 1 of 3 rodent malaria species: Plasmodium chabaudi chabaudi, P. vinck ei petteri and P. yoelii nigeriensis at different times during the course o f the primary parasitaemia and long after microscopical clearance of the pa rasites. Moreover, similar lesions were also obtained when parasite levels were kept below 1 % by subcurative drug treatment. The frequency and severi ty of the lesions correlated with the duration of the infection. Accumulati on of tissue damage during chronic low-grade malaria infections has implica tions for the design of control measures.